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Safe mode typically refers to a state in which certain functions or operations of a device or system are restricted or disabled to prevent potential issues or damage. In the context of Labjack acquisition and serial streams, it's not typical for these processes to continue running while the device is in safe mode. However, the behavior can vary depending on how the safe mode is implemented in your specific setup. Some systems might have different levels of safe mode, where certain critical operations are stopped while others are allowed to continue.

Even though you've set Windows 10 to keep the screen on and prevent the hard drive from sleeping, there might be other power management settings affecting the USB ports or network adapters. Check the power management settings for these devices in Device Manager and ensure that they are set to "Allow the computer to turn off this device to save power" is unchecked. Windows 10 has a feature called USB Selective Suspend, which can selectively suspend USB devices to save power. This could be affecting your USB-connected SDI-12 converter. You can disable this feature by going to Control Panel > Power Options > Change plan settings > Change advanced power settings > USB settings > USB selective suspend setting, and set it to Disabled.